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Androgen receptor signaling

Breaking apart condensates

Nature Chemical Biology volume 18, pages 1292–1293 (2022)Cite this article

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Prostate tumors, resistant to current antiandrogen therapies, represent a serious clinical challenge. A new report identifies androgen-receptor-dependent liquid condensates as being responsible in part for therapeutic resistance, but, encouragingly, also reveals a novel vulnerability amenable to drug targeting.

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Fig. 1: Targeting androgen receptor liquid–liquid phase separation to switch off receptor activity in prostate cancer cells.

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  1. Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK

    Iain J. McEwan

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  1. Iain J. McEwan
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Correspondence to Iain J. McEwan.

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McEwan, I.J. Breaking apart condensates. Nat Chem Biol 18, 1292–1293 (2022). https://doi.org/10.1038/s41589-022-01161-w

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