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Gut microbiota

Disarming the pathogen

The gut microbiota has a key role in protecting hosts from pathogens. A new study identified a gut microbiota-derived bile acid (chenodeoxycholic acid) that inhibits bacterial infection by interacting with a regulatory protein necessary for the expression of virulence factors.

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Fig. 1: Gut microbiota-derived CDCA deactivates Salmonella virulence.


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Correspondence to Víctor H. Bustamante.

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Pérez-Morales, D., Bustamante, V.H. Disarming the pathogen. Nat Chem Biol (2022).

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