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Gut microbiota

Disarming the pathogen

The gut microbiota has a key role in protecting hosts from pathogens. A new study identified a gut microbiota-derived bile acid (chenodeoxycholic acid) that inhibits bacterial infection by interacting with a regulatory protein necessary for the expression of virulence factors.

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Fig. 1: Gut microbiota-derived CDCA deactivates Salmonella virulence.

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Correspondence to Víctor H. Bustamante.

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Pérez-Morales, D., Bustamante, V.H. Disarming the pathogen. Nat Chem Biol (2022). https://doi.org/10.1038/s41589-022-01133-0

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  • DOI: https://doi.org/10.1038/s41589-022-01133-0

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