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KINASE INHIBITORS

Aiming for the pocket

Nature Chemical Biology volume 18, pages 1296–1297 (2022)Cite this article

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Isoform-selective inhibition of JAK kinases is of key interest in drug discovery. A novel pocket in the JAK pseudokinase domain was targeted by an allosteric covalent inhibitor, leading to specific JAK1 inhibition and providing a deeper understanding of cytokine signaling.

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Fig. 1: JAK1 inhibition by VVD-118313.

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Authors and Affiliations

  1. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

    Olli Silvennoinen, Teemu Haikarainen & Anniina Virtanen

  2. Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland

    Olli Silvennoinen & Anniina Virtanen

Authors
  1. Olli Silvennoinen
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  2. Teemu Haikarainen
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  3. Anniina Virtanen
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Corresponding author

Correspondence to Olli Silvennoinen.

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Competing interests

O.S. holds intellectual property rights to JAK kinases, is a scientific advisory board member and co-founder of Ajax Therapeutics and has received speaking honoraria from Pfizer and Abbvie.

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Silvennoinen, O., Haikarainen, T. & Virtanen, A. Aiming for the pocket. Nat Chem Biol 18, 1296–1297 (2022). https://doi.org/10.1038/s41589-022-01120-5

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