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NANOMEDICINE

Unbiased matchmaking

Elucidating the interactions between serum protein-bound nanoparticles and cell-surface receptors typically operates on a per protein–receptor interaction basis. Integration of omic approaches for testing thousands of interactions unbiasedly reveals important interactions that drive cellular uptake of nanoparticles.

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Fig. 1: Experimental framework for the unbiased elucidation of pairwise interactions between protein corona and cell-surface receptors.

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Correspondence to Chung Hang Jonathan Choi.

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Chan, C.K.W., Lau, S.H.G. & Choi, C.H.J. Unbiased matchmaking. Nat Chem Biol 18, 921–923 (2022). https://doi.org/10.1038/s41589-022-01108-1

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