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Selective uptake of a DNA gyrase poison kills Mycobacterium tuberculosis

Photorhabdus noenieputensis (a gut microbiota symbiont of nematodes) produces a macrocyclic antibiotic, evybactin, that selectively kills Mycobacterium tuberculosis (Mtb). The Mtb membrane transporter BacA imports evybactin into the cell, where it binds to DNA gyrase and causes cell death.

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Fig. 1: Evybactin enters Mtb via BacA and binds to DNA gyrase.

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This is a summary of: Imai, Y. et al. Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01102-7 (2022).

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Selective uptake of a DNA gyrase poison kills Mycobacterium tuberculosis. Nat Chem Biol 18, 1174–1175 (2022). https://doi.org/10.1038/s41589-022-01103-6

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