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Voyage to minimal base editors

Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

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Fig. 1: Size comparison of diverse Cas nucleases and TnpBs.


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Correspondence to Sangsu Bae.

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Song, B., Bae, S. Voyage to minimal base editors. Nat Chem Biol 18, 920–921 (2022).

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