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Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules

The microtubule-associated protein tau is strongly linked to Alzheimer’s disease, but the physiological functions of tau on microtubules remain unclear. New experiments reveal that tau recognizes and alters the conformation of the underlying microtubule lattice by forming envelopes that surround its surface, suggestive of a novel role for tau in cell physiology.

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Fig. 1: MAP envelopes compact the microtubule lattice.

References

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This is a summary of: Siahaan, V. et al. Microtubule lattice spacing governs cohesive envelope formation of tau family proteins. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01096-2 (2022).

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Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules. Nat Chem Biol 18, 1172–1173 (2022). https://doi.org/10.1038/s41589-022-01097-1

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