Biomolecular condensates form and dissolve in response to a wide range of signals. A new study reports a solubility-based phosphoproteome-profiling approach, which uncovers the extensive role of phosphorylation in regulating protein partitioning into condensates across the human proteome.
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The authors are full-time employees at Dewpoint Therapeutics, a biotechnology company leading condensate drug discovery and development. The authors declare that this affiliation has not compromised the perspective provided here.
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Rizzolo, K., Mitrea, D.M. Flipping the switch. Nat Chem Biol 18, 1041–1042 (2022). https://doi.org/10.1038/s41589-022-01075-7
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DOI: https://doi.org/10.1038/s41589-022-01075-7
