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IMMUNOLOGY

Chaperoning the dance of antigen presentation

Antigen loading onto class I major histocompatibility complex (MHC-I) proteins relies on chaperones and protein flexibility. Researchers now provide new insight into the process, especially for the intriguing ‘non-classical’ MHC-I protein MR1, with implications for fundamental immunology and the development of novel immunotherapies.

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Fig. 1: Differences in the dynamics of empty MHC-I and MR1 proteins alter recognition by TAPBPR.

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Correspondence to Brian M. Baker.

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Rosales, T.J., Baker, B.M. Chaperoning the dance of antigen presentation. Nat Chem Biol 18, 796–797 (2022). https://doi.org/10.1038/s41589-022-01069-5

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