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Putting a leash on Hippo

The Hippo pathway is a key regulator of tissue homeostasis, organ size and cancer. Identification of microcolin B and its analog molecules as Hippo pathway activators connects PtdIns4P-dependent lipid signaling with the Hippo pathway, suggesting potential targets for cancer therapy.

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Fig. 1: Phospholipids are key regulators of the Hippo pathway.


  1. Zheng, Y. & Pan, D. Dev. Cell 50, 264–282 (2019).

    CAS  Article  Google Scholar 

  2. Zanconato, F., Cordenonsi, M. & Piccolo, S. Cancer Cell 29, 783–803 (2016).

    CAS  Article  Google Scholar 

  3. Dey, A., Varelas, X. & Guan, K. L. Nat. Rev. Drug Discov. 19, 480–494 (2020).

    CAS  Article  Google Scholar 

  4. Li, F. L. et al. Nat. Chem. Biol. (2022).

  5. Koehn, F. E., Longley, R. E. & Reed, J. K. J. Nat. Prod. 55, 613–619 (1992).

    CAS  Article  Google Scholar 

  6. Mani, T. et al. Mol. Cell. Biol. 31, 1983–1996 (2011).

    CAS  Article  Google Scholar 

  7. Hong, A. W. et al. Genes Dev. 34, 511–525 (2020).

    CAS  Article  Google Scholar 

  8. Yu, F. X. et al. Cell 150, 780–791 (2012).

    CAS  Article  Google Scholar 

  9. Miller, E. et al. Chem. Biol. 19, 955–962 (2012).

    CAS  Article  Google Scholar 

  10. Han, H. et al. Mol. Cell 72, 328–340 e8 (2018).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Wenqi Wang.

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Seo, G., Wang, W. Putting a leash on Hippo. Nat Chem Biol (2022).

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