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Putting a leash on Hippo

The Hippo pathway is a key regulator of tissue homeostasis, organ size and cancer. Identification of microcolin B and its analog molecules as Hippo pathway activators connects PtdIns4P-dependent lipid signaling with the Hippo pathway, suggesting potential targets for cancer therapy.

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Fig. 1: Phospholipids are key regulators of the Hippo pathway.

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Correspondence to Wenqi Wang.

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Seo, G., Wang, W. Putting a leash on Hippo. Nat Chem Biol (2022). https://doi.org/10.1038/s41589-022-01066-8

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  • DOI: https://doi.org/10.1038/s41589-022-01066-8

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