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Catch your breath

Carbon dioxide (CO2) is a product of cellular respiration that can also serve as a post-translational modification (PTM) through covalent protein modification. A new chemoproteomic strategy enables the capture of functional CO2-dependent carboxylation on lysine residues of proteins.

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Fig. 1: Homocitrullination enables chemoproteomic identification of CO2-reactive lysines through competitive labeling.


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Correspondence to Ku-Lung Hsu.

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Grams, R.J., Hsu, KL. Catch your breath. Nat Chem Biol 18, 686–687 (2022).

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