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POST-TRANSLATIONAL MODIFICATIONS

Catch your breath

Nature Chemical Biology volume 18, pages 686–687 (2022)Cite this article

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Carbon dioxide (CO2) is a product of cellular respiration that can also serve as a post-translational modification (PTM) through covalent protein modification. A new chemoproteomic strategy enables the capture of functional CO2-dependent carboxylation on lysine residues of proteins.

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Fig. 1: Homocitrullination enables chemoproteomic identification of CO2-reactive lysines through competitive labeling.

References

  1. King, D. T. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01043-1 (2022).

    Article  PubMed  Google Scholar 

  2. Cummins, E. P., Strowitzki, M. J. & Taylor, C. T. Physiol. Rev. 100, 463–488 (2020).

    Article  CAS  Google Scholar 

  3. Cummins, E. P., Selfridge, A. C., Sporn, P. H., Sznajder, J. I. & Taylor, C. T. Cell. Mol. Life Sci. 71, 831–845 (2014).

    Article  CAS  Google Scholar 

  4. Mackinder, L. C. M. et al. Cell 171, 133–147 e14 (2017).

    Article  CAS  Google Scholar 

  5. Ewing, S. P., Lockshon, D. & Jencks, W. P. J. Am. Chem. Soc. 102, 3072–3084 (1980).

    Article  CAS  Google Scholar 

  6. Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J. P. & Mobashery, S. Proc. Natl Acad. Sci. USA 98, 14280–14285 (2001).

    Article  CAS  Google Scholar 

  7. Jabri, E., Carr, M. B., Hausinger, R. P. & Karplus, P. A. Science 268, 998–1004 (1995).

    Article  CAS  Google Scholar 

  8. Linthwaite, V. L. et al. Nat. Commun. 9, 3092 (2018).

    Article  Google Scholar 

  9. Stec, B. Proc. Natl Acad. Sci. USA 109, 18785–18790 (2012).

    Article  CAS  Google Scholar 

  10. Wang, Z. et al. Nat. Med. 13, 1176–1184 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry, University of Virginia, Charlottesville, VA, USA

    R. Justin Grams & Ku-Lung Hsu

  2. Department of Pharmacology, , University of Virginia School of Medicine, Charlottesville, VA, USA

    Ku-Lung Hsu

  3. Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA

    Ku-Lung Hsu

  4. University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA

    Ku-Lung Hsu

Authors
  1. R. Justin Grams
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  2. Ku-Lung Hsu
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Correspondence to Ku-Lung Hsu.

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The authors declare no competing interests.

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Grams, R.J., Hsu, KL. Catch your breath. Nat Chem Biol 18, 686–687 (2022). https://doi.org/10.1038/s41589-022-01063-x

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