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GLYCOBIOLOGY

Mucin modulates microbial morphogenesis

The rising threat of antifungal resistance means that alternative therapeutics need to be considered. New research explores the biochemical basis of virulence inhibition by mucus glycans against the fungal pathogen Candida albicans.

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Fig. 1: Understanding the impact of mucin O-glycans on the virulence of C. albicans.

References

  1. Fisher, M. C. et al. mBio 11, e00449–20 (2020).

    PubMed  PubMed Central  Google Scholar 

  2. Sharma, J., Rosiana, S., Razzaq, I. & Shapiro, R. J. Fungi 5, 17 (2019).

    Article  CAS  Google Scholar 

  3. Kavanaugh, N. L., Zhang, A. Q., Nobile, C. J., Johnson, A. D. & Ribbeck, K. mBio 5, e01911 (2014).

    Article  CAS  Google Scholar 

  4. Takagi, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01035-1 (2022).

    Article  PubMed  Google Scholar 

  5. Romo, J. A. et al. mBio 8, e01991–17 (2017).

    Article  CAS  Google Scholar 

  6. MacAlpine, J. et al. Nat. Commun. 12, 6151 (2021).

    Article  CAS  Google Scholar 

  7. Wagner, C. E., Wheeler, K. M. & Ribbeck, K. Annu. Rev. Cell Dev. Biol. 34, 189–215 (2018).

    Article  CAS  Google Scholar 

  8. Witchley, J. N. et al. Cell Host Microbe 25, 432–443.e6 (2019).

    Article  CAS  Google Scholar 

  9. Pruss, K. M. et al. ISME J. 15, 577–591 (2021).

    Article  CAS  Google Scholar 

  10. Tan, C. T., Xu, X., Qiao, Y. & Wang, Y. Nat. Commun. 12, 2560 (2021).

    Article  CAS  Google Scholar 

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Correspondence to Rebecca S. Shapiro.

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Sharma, J., Shapiro, R.S. Mucin modulates microbial morphogenesis. Nat Chem Biol 18, 684–686 (2022). https://doi.org/10.1038/s41589-022-01053-z

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