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Making a 6mA demethylase

An Author Correction to this article was published on 07 July 2022

This article has been updated

A fungal ten-eleven translocation (TET) dioxygenase homolog, CcTet, is found to have both 5-methylcytosine (5mC) and N6-methyladenine (6mA) demethylase activity. Structure-based engineering of CcTet yielded a 6mA-specific demethylase, offering a useful tool for the manipulation and functional study of 6mA.

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Fig. 1: The 6mA demethylases.

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Correspondence to Sisi Li or Jiamu Du.

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Li, S., Du, J. Making a 6mA demethylase. Nat Chem Biol 18, 683–684 (2022).

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