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Putting introns on retainer

Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.

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Fig. 1: Antitumoral immune response triggered by retained introns.


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Correspondence to Stéphane Richard.

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Srour, N., Richard, S. Putting introns on retainer. Nat Chem Biol (2022).

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