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Microproteins — lost in translation

Microproteins can be generated by a shift in the reading frame during translation. A chemoproteomics approach led to the identification of MINAS-60 as an alternative microprotein that regulates the assembly of the pre-60S ribosome.

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Fig. 1: Overview of the BONCAT method and proposed function of MINAS-60.


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Correspondence to Stephan Wenkel.

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The authors declare no competing interests.

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Kruusvee, V., Wenkel, S. Microproteins — lost in translation. Nat Chem Biol 18, 581–582 (2022).

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