The cryo-electron microscopy structure of a fluoroquinolone efflux transporter, NorA, in complex with an antibody fragment provides a new strategy whereby peptide inhibitors derived from antibody loops could be used to block antibiotic efflux in a drug-resistant superbug.
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References
Du, D. et al. Nat. Rev. Microbiol. 16, 523–539 (2018).
Paulsen, I. T., Brown, M. H. & Skurray, R. A. Microbiol. Rev. 60, 575–608 (1996).
Yoshida, H., Bogaki, M., Nakamura, S., Ubukata, K. & Konno, M. J. Bacteriol. 172, 6942–6949 (1990).
Papkou, A., Hedge, J., Kapel, N., Young, B. & MacLean, R. C. Nat. Commun. 11, 3970 (2020).
Dashtbani-Roozbehani, A. & Brown, M. Antibiotics (Basel) 10, 1502 (2021).
Wright, G. D. Trends Microbiol. 24, 862–871 (2016).
Brawley, D. N. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-00994-9 (2022).
Kumar, S. et al. Commun. Biol. 4, 836 (2021).
Nygaard, R., Kim, J. & Mancia, F. Curr. Opin. Struct. Biol. 64, 26–33 (2020).
Neyfakh, A. A., Borsch, C. M. & Kaatz, G. W. Antimicrob. Agents Chemother. 37, 128–129 (1993).
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Penmatsa, A. A (Fab)ulous tool to block efflux. Nat Chem Biol 18, 681–682 (2022). https://doi.org/10.1038/s41589-022-00999-4
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DOI: https://doi.org/10.1038/s41589-022-00999-4
