Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CATALYTIC RNA

A new RNA performs old chemistry

Nature Chemical Biology volume 18, pages 438–439 (2022)Cite this article

Subjects

Natural self-cleaving RNAs employ a wide range of catalytic strategies, but it is not known whether artificial ribozymes are capable of the same catalytic diversity. New structures of a methyltransferase ribozyme reveal the potential variety of RNA reactions and mechanisms.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Catalysis by MTR1.

References

  1. Scheitl, C. M. P., Mieczkowski, M., Schindelin, H. & Höbartner, C. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-00976-x (2022).

  2. Deng, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-00982-z (2022).

  3. Wilson, T. J., Liu, Y. & Lilley, D. M. J. Front. Chem. Sci. Eng. 10, 178–185 (2016).

    Article  CAS  Google Scholar 

  4. Serganov, A. et al. Nat. Struct. Mol. Biol. 12, 218–224 (2005).

    Article  CAS  Google Scholar 

  5. Xiao, H., Murakami, H., Suga, H. & Ferré-D'Amaré, A. R. Nature 454, 358–361 (2008).

    Article  CAS  Google Scholar 

  6. Krochmal, D. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00950-z (2022).

    Article  PubMed  Google Scholar 

  7. Rodnina, M. V. Curr. Opin. Struct. Biol. 23, 595–602 (2013).

    Article  CAS  Google Scholar 

  8. Flemmich, L., Heel, S., Moreno, S., Breuker, K. & Micura, R. Nat. Commun. 12, 3877 (2021).

    Article  CAS  Google Scholar 

  9. Jiang, H. et al. Nat. Catal. 4, 872–881 (2021).

    Article  CAS  Google Scholar 

  10. Scheitl, C. P. M., Ghaem Maghami, M., Lenz, A. K. & Höbartner, C. Nature 587, 663–667 (2020).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry and the Institute of Biomolecular Design and Discovery, Yale University, New Haven, CT, USA

    David A. Hiller & Scott A. Strobel

Authors
  1. David A. Hiller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Scott A. Strobel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Scott A. Strobel.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hiller, D.A., Strobel, S.A. A new RNA performs old chemistry. Nat Chem Biol 18, 438–439 (2022). https://doi.org/10.1038/s41589-022-00998-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-022-00998-5

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing