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REDOX BIOLOGY

Oxidize me to the space

Chemoproteomics reveals a cysteine oxidation event that inhibits the maturation process of a lysosomal protease, enabling its secretion into the extracellular space during infection-induced tumorigenesis. A recent study offers a new mechanistic paradigm for redox-dependent regulation of protein trafficking.

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Fig. 1: Infection-induced oxidation of lysosomal prolegumain leads to its mis-trafficking into the extracellular space during tumorigenesis.

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Correspondence to Jing Yang.

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Yang, J. Oxidize me to the space. Nat Chem Biol 18, 680–681 (2022). https://doi.org/10.1038/s41589-022-00986-9

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  • DOI: https://doi.org/10.1038/s41589-022-00986-9

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