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PRECISION ONCOLOGY

Drivers of intrinsic resistance

Nature Chemical Biology volume 18, pages 579–581 (2022)Cite this article

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Precision oncology requires an understanding of the genes and pathways that dictate therapeutic response. Through specialized analysis of drug sensitivity patterns across hundreds of genomically annotated cancer cell lines, specific and actionable drivers of intrinsic resistance have been identified.

There exists a large and rapidly growing armamentarium of drugs targeting diverse biological processes required for cancer cell survival. However, deploying these agents with precision — for example, in the proper tumor genomic contexts or drug combinations — requires a nuanced understanding of the genes and pathways that dictate response to each drug1,2. Various correlative and functional approaches have been developed to address this challenge. In this issue of Nature Chemical Biology, Rees et al. add a new approach, demonstrating that recurrent, specific and often actionable drivers of intrinsic drug resistance can be identified by carefully integrating transcriptional profiles of cancer cell lines with their drug response behaviors3.

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Fig. 1: Discovery of actionable genes driving intrinsic resistance.

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  1. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA

    Kris C. Wood

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  1. Kris C. Wood
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Correspondence to Kris C. Wood.

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The author declares no competing financial interest.

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Wood, K.C. Drivers of intrinsic resistance. Nat Chem Biol 18, 579–581 (2022). https://doi.org/10.1038/s41589-022-00980-1

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