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CRISP(e)R drug discovery

Pharmacological agents exert their therapeutic effects by altering the biochemical activities of drug targets and, consequently, manipulating cell and organism physiology. A new study combines CRISPR interference with metabolomic profiling to rapidly elucidate drug mechanisms of action.

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Fig. 1: Discovery of drug mechanisms of action by CRISPRi and untargeted metabolomics.


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Correspondence to Jason H. Yang.

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Yang, J.H. CRISP(e)R drug discovery. Nat Chem Biol 18, 435–436 (2022).

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