Pharmacological agents exert their therapeutic effects by altering the biochemical activities of drug targets and, consequently, manipulating cell and organism physiology. A new study combines CRISPR interference with metabolomic profiling to rapidly elucidate drug mechanisms of action.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Moffat, J. G., Vincent, F., Lee, J. A., Eder, J. & Prunotto, M. Nat. Rev. Drug Discov. 16, 531–543 (2017).
Anglada-Girotto, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-00970-3 (2022).
Wishart, D. S. et al. Nucleic Acids Res. 46, D1074–D1082 (2017).
Schenone, M., Dančík, V., Wagner, B. K. & Clemons, P. A. Nat. Chem. Biol. 9, 232–240 (2013).
Perlman, Z. E. et al. Science 306, 1194–1198 (2004).
Gardner, T. S., Bernardo, D. D., Lorenz, D. & Collins, J. J. Science 301, 102–105 (2003).
Litichevskiy, L. et al. Cell Syst. 6, 424–443.e427 (2018).
Zampieri, M. et al. Sci. Transl. Med. 10, eaal3973 (2018).
Fuhrer, T., Zampieri, M., Sévin, D. C., Sauer, U. & Zamboni, N. Mol. Syst. Biol. 13, 907 (2017).
Yang, J. H. et al. Cell 177, 1649–1661.e1649 (2019).
The author declares no competing interests.
About this article
Cite this article
Yang, J.H. CRISP(e)R drug discovery. Nat Chem Biol 18, 435–436 (2022). https://doi.org/10.1038/s41589-022-00979-8