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Picturing protein disaggregation

Just how chaperones clear protein aggregates is a notoriously impenetrable problem. A new study now shows how single-molecule movies of Hsp104 and Hsp70 chaperones acting on amyloid fibers are the key to revealing their underlying cooperation in time and space.

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Fig. 1: Single-molecule observation of amyloid disaggregation by Hsp104.


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Correspondence to Sander J. Tans.

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Tans, S.J. Picturing protein disaggregation. Nat Chem Biol 18, 240–241 (2022).

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