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GPCR STRUCTURAL BIOLOGY

Scratching the itch with cryo-EM

Nature Chemical Biology volume 18, pages 242–243 (2022)Cite this article

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Cryo-EM structures of Mas-related G-protein-coupled receptors (MRGPRs) that are involved in the allergic reaction and itch response reveal structural insights into their activation mechanism, and offer the potential to discover new therapeutic agents for pain and hypersensitivity reactions.

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Fig. 1: The structure and function of MRGPRX2.

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Authors and Affiliations

  1. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India

    Jagannath Maharana, Parishmita Sarma & Arun K. Shukla

Authors
  1. Jagannath Maharana
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  2. Parishmita Sarma
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  3. Arun K. Shukla
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Correspondence to Arun K. Shukla.

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The authors declare no competing interests.

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Maharana, J., Sarma, P. & Shukla, A.K. Scratching the itch with cryo-EM. Nat Chem Biol 18, 242–243 (2022). https://doi.org/10.1038/s41589-021-00959-4

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