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XaaP-ing DPP8/9 for CARD8 activation

Inflammasomes are cytosolic immune complexes that initiate inflammatory signaling upon pathogen recognition. A new paper reveals that inhibition of M24B aminopeptidases drives the selective activation of the CARD8 inflammasome, providing new insights into its regulation.

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Fig. 1: Selective activation of the CARD8 inflammasome.


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Correspondence to Patrick S. Mitchell.

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Kulsuptrakul, J., Mitchell, P.S. XaaP-ing DPP8/9 for CARD8 activation. Nat Chem Biol 18, 439–440 (2022).

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