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INFLAMMASOMES

XaaP-ing DPP8/9 for CARD8 activation

Nature Chemical Biology volume 18, pages 439–440 (2022)Cite this article

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Inflammasomes are cytosolic immune complexes that initiate inflammatory signaling upon pathogen recognition. A new paper reveals that inhibition of M24B aminopeptidases drives the selective activation of the CARD8 inflammasome, providing new insights into its regulation.

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Fig. 1: Selective activation of the CARD8 inflammasome.

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Authors and Affiliations

  1. Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA

    Jessie Kulsuptrakul

  2. Department of Microbiology, University of Washington, Seattle, Washington, USA

    Patrick S. Mitchell

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  1. Jessie Kulsuptrakul
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  2. Patrick S. Mitchell
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Correspondence to Patrick S. Mitchell.

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The authors declare no competing financial interest.

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Kulsuptrakul, J., Mitchell, P.S. XaaP-ing DPP8/9 for CARD8 activation. Nat Chem Biol 18, 439–440 (2022). https://doi.org/10.1038/s41589-021-00958-5

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