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SYNTHETIC BIOLOGY

CAR-T cells SEAK help from enzymes

Nature Chemical Biology volume 18, pages 122–123 (2022)Cite this article

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Chimeric antigen receptor T cells (CAR-T cells) are often hindered by the concurrent challenges of variable antigen expression patterns and immunosuppressive tumor microenvironments. A new approach enhances CAR-T cells by coexpressing bacterial enzymes that activate prodrugs in high concentrations at the disease site.

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Fig. 1: 'SEAKER' cells for dual-mode tumor lysis.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Columbia University, New York, NY, USA

    Rosa Vincent & Tal Danino

  2. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA

    Tal Danino

  3. Data Science Institute, Columbia University, New York, NY, USA

    Tal Danino

Authors
  1. Rosa Vincent
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  2. Tal Danino
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Correspondence to Tal Danino.

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The authors declare no competing financial interests.

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Vincent, R., Danino, T. CAR-T cells SEAK help from enzymes. Nat Chem Biol 18, 122–123 (2022). https://doi.org/10.1038/s41589-021-00933-0

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