Chimeric antigen receptor T cells (CAR-T cells) are often hindered by the concurrent challenges of variable antigen expression patterns and immunosuppressive tumor microenvironments. A new approach enhances CAR-T cells by coexpressing bacterial enzymes that activate prodrugs in high concentrations at the disease site.
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Gardner, T. J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00932-1 (2021).
Majzner, R. G. & Mackall, C. L. Cancer Discov. 8, 1219–1226 (2018).
Hyrenius-Wittsten, A. & Roybal, K. T. Trends. Cancer 5, 583–592 (2019).
Gardner, T. J. et al. Cancers 12, 2175 (2020).
Sharma, S. K. & Bagshawe, K. D. Expert Opin. Biol. Th. 17, 1–13 (2016).
Roybal, K. T. et al. Cell 167, 419–432.e16 (2016).
Choi, B. D. et al. Nat. Biotechnol. 37, 1049–1058 (2019).
Sukumaran, S. et al. Cancer Discov. 8, 972–987 (2018).
Huang, X. et al. Nat. Nanotechnol. 16, 214–223 (2021).
Park, A. K. et al. Science Transl. Med. 12, eaaz1863 (2020).
The authors declare no competing financial interests.
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Vincent, R., Danino, T. CAR-T cells SEAK help from enzymes. Nat Chem Biol 18, 122–123 (2022). https://doi.org/10.1038/s41589-021-00933-0