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Treating diabetes with ‘cookies’

Genetic code expansion is emerging as a promising strategy to precisely regulate protein expression. A new study engineered cells that enabled noncanonical-amino-acid-triggered insulin expression to rapidly regulate blood glucose levels in a diabetic mouse model.

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Fig. 1: NcAA ‘cookies’ trigger insulin production to lower blood glucose levels in diabetic mice.


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Correspondence to Yuqi Zhang or Zhen Gu.

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Competing interests

Z.G. is the co-founder of Zenomics, Zencapsule, ZCapsule, and Wskin.

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Yu, J., Zhang, Y. & Gu, Z. Treating diabetes with ‘cookies’. Nat Chem Biol 18, 3–4 (2022).

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