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There is a lock for every key

Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.

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Fig. 1: A chemoproteomics screen using a photocrosslinkable and clickable oxysterol probe revealed that 20(S)-OHC is an endogenous ligand of the σ2 receptor (TMEM97).


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Correspondence to Jeremy M. Baskin.

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Yu, W., Baskin, J.M. There is a lock for every key. Nat Chem Biol 17, 1214–1216 (2021).

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