RNA modifications are emerging regulators of development and disease. A metabolic labeling approach using 5-fluorocytidine (5-FCyd) allows the mechanism-based profiling of several RNA-modifying enzymes and potentially links their activity to novel RNA targets.
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Thalalla Gamage, S., Meier, J.L. Activity-based profiling in RNA. Nat Chem Biol 17, 1121–1122 (2021). https://doi.org/10.1038/s41589-021-00879-3
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DOI: https://doi.org/10.1038/s41589-021-00879-3
