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TOXIN–ANTITOXIN SYSTEMS

Evolving complex insulation

Nature Chemical Biology volume 17, pages 1216–1217 (2021)Cite this article

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Prokaryotic genomes are rife with highly similar toxin–antitoxin modules that need to be protected and diversified at the same time. Studies of paralogous modules now reveal how evolution secures insulation between related systems, without compromising toxin inhibition.

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Fig. 1: Structural characterization of TacAT2 and evolutionary model leading to TacAT insulation.

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Anastasia Liuzzi & Ditlev E. Brodersen

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  1. Anastasia Liuzzi
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  2. Ditlev E. Brodersen
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Correspondence to Ditlev E. Brodersen.

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The authors declare no competing interest.

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Liuzzi, A., Brodersen, D.E. Evolving complex insulation. Nat Chem Biol 17, 1216–1217 (2021). https://doi.org/10.1038/s41589-021-00873-9

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