RNA knot-like structures function as an efficient physical barrier to RNA exoribonucleases. Single-molecule mechanical manipulation is used to unfold these structures and unravel the cause of their unusual mechanical resistance from a different direction.
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Li, P.T.X. Untying knots with force. Nat Chem Biol 17, 933–934 (2021). https://doi.org/10.1038/s41589-021-00856-w