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A roadmap to creating ferroptosis-based medicines

Nature Chemical Biology volume 17, pages 1113–1116 (2021)Cite this article

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Ferroptosis is a regulated form of non-apoptotic cell death implicated in pathological settings. To be exploited clinically, ferroptosis requires reagents that unequivocally detect ferroptosis in human and animal tissues. Such tools may enable development of ferroptosis-based medicines for diverse diseases.

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Fig. 1: Major ferroptosis regulators and small-molecule modulators.
Fig. 2: Ferroptosis detection and classification.

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Author information

Authors and Affiliations

  1. Assay Development and Screening Platform, Helmholtz Zentrum München, Neuherberg, Germany

    Kamyar Hadian

  2. Department of Biological Sciences, Columbia University, New York, USA

    Brent R. Stockwell

  3. Department of Chemistry, Columbia University, New York, USA

    Brent R. Stockwell

Authors
  1. Kamyar Hadian
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  2. Brent R. Stockwell
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Corresponding authors

Correspondence to Kamyar Hadian or Brent R. Stockwell.

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Competing interests

K.H. declares no competing financial interest. B.R.S. is an inventor on patents and patent applications involving ferroptosis, co-founded and serves as a consultant to Inzen Therapeutics and Nevrox Limited, and serves as a consultant to Weatherwax Biotechnologies Corporation.

Additional information

Peer review information Nature Chemical Biology thanks Jose Pedro Friedmann Angeli, Yilong Zou and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Hadian, K., Stockwell, B.R. A roadmap to creating ferroptosis-based medicines. Nat Chem Biol 17, 1113–1116 (2021). https://doi.org/10.1038/s41589-021-00853-z

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