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PHASE SEPARATION

Insulating proteins drop by drop

Liquid–liquid phase separation, yielding membraneless organelles, allows for the sequestration and functional insulation of cellular proteins. A modularly built, synthetic membraneless organelle platform enables efficient control over endogenous cellular activities by knockdown of protein function or controlled protein release.

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Fig. 1: LLPS-based insulation of endogenous enzymes.

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Correspondence to Ulrich Krauss.

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Krauss, U. Insulating proteins drop by drop. Nat Chem Biol 17, 934–936 (2021). https://doi.org/10.1038/s41589-021-00846-y

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