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Fighting PRC1 via the RING

Over the past two decades, inhibitors of the polycomb repressor complex (PRC) have been driven from bench to bedside. New chemical compounds targeting the RING1B in polycomb repressor complex 1 (PRC1) add important tools to regulate polycomb functions.

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Fig. 1: Inhibitors of polycomb complexes.


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Correspondence to Joshua P. Plotnik.

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J.P.P. is an employee of AbbVie Inc.

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Plotnik, J.P. Fighting PRC1 via the RING. Nat Chem Biol 17, 753–754 (2021).

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