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Cancer signaling

A stop sign for RAS trafficking

N-Ras lipidation cycling is known to regulate its trafficking and function. A new S-depalmitoylation inhibitor induces N-Ras membrane mislocalization, providing insights into N-Ras function and laying the foundation for a new cancer therapeutic strategy.

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Fig. 1: ABD957, a newly described selective covalent inhibitor of the ABHD17 family of depalmitoylases, impairs N-Ras depalmitoylation and disrupts its subcellular localization.


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Correspondence to Bryan C. Dickinson.

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Qiu, T., Dickinson, B.C. A stop sign for RAS trafficking. Nat Chem Biol (2021).

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