N-Ras lipidation cycling is known to regulate its trafficking and function. A new S-depalmitoylation inhibitor induces N-Ras membrane mislocalization, providing insights into N-Ras function and laying the foundation for a new cancer therapeutic strategy.
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References
Lin, D. T. S. & Conibear, E. eLife 4, e11306 (2015).
Remsberg, J. R. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00785-8 (2021).
Rocks, O. et al. Science 307, 1746–1752 (2005).
Swarthout, J. T. et al. J. Biol. Chem. 280, 31141–31148 (2005).
Dekker, F. J. et al. Nat. Chem. Biol. 6, 449–456 (2010).
Yokoi, N. et al. J. Neurosci. 36, 6431–6444 (2016).
Cao, Y. et al. Nat. Chem. Biol. 15, 1232–1240 (2019).
Cuiffo, B. & Ren, R. Blood 115, 3598–3605 (2010).
Davda, D. et al. ACS Chem. Biol. 8, 1912–1917 (2013).
McClafferty, H., Runciman, H. & Shipston, M. J. J. Biol. Chem. 295, 16487–16496 (2020).
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Qiu, T., Dickinson, B.C. A stop sign for RAS trafficking. Nat Chem Biol 17, 840–841 (2021). https://doi.org/10.1038/s41589-021-00789-4
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DOI: https://doi.org/10.1038/s41589-021-00789-4
