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Mining for mouth metabolites

Genome mining of Streptococcus mutans clinical samples led to the identification of a structurally unique polyketide/non-ribosomal peptide, mutanofactin-697, that promotes biofilm formation. This study highlights the unexplored functional potential of secondary metabolites and opens new avenues for inhibiting pathogenic processes.

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Fig. 1: Secondary metabolite induces biofilm formation.

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Correspondence to William M. Wuest.

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Scharnow, A.M., Wuest, W.M. Mining for mouth metabolites. Nat Chem Biol 17, 505–506 (2021). https://doi.org/10.1038/s41589-021-00784-9

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