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Hunting for human ribozymes

An approach based on enrichment of 5′ hydroxylated RNAs reveals a new self-cleaving ribozyme that maps to a very long non-protein-coding RNA in simians. The ribozyme is active only among hominin sequences, suggesting a recent acquisition of the activity.

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Fig. 1: Discovery of the hovlinc ribozyme.


  1. 1.

    Weinberg, C. E., Weinberg, Z. & Hammann, C. Nucleic Acids Res. 47, 9480–9494 (2019).

    CAS  Article  Google Scholar 

  2. 2.

    Chen, Y. et. al. Nat. Chem. Biol. (2021).

  3. 3.

    Salehi-Ashtiani, K., Lupták, A., Litovchick, A. & Szostak, J. W. Science 313, 1788–1792 (2006).

    CAS  Article  Google Scholar 

  4. 4.

    Jimenez, R. M., Polanco, J. A. & Lupták, A. Trends Biochem. Sci. 40, 648–661 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    de la Peña, M. & García-Robles, I. EMBO Rep. 11, 711–716 (2010).

    Article  Google Scholar 

  6. 6.

    Perreault, J. et al. PLOS Comput. Biol. 7, e1002031 (2011).

    CAS  Article  Google Scholar 

  7. 7.

    Martick, M., Horan, L. H., Noller, H. F. & Scott, W. G. Nature 454, 899–902 (2008).

    CAS  Article  Google Scholar 

  8. 8.

    Hernandez, A. J. et al. Proc. Natl. Acad. Sci. USA 117, 415–425 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Chen, C. C. et al. Preprint at bioRxiv (2021).

  10. 10.

    Ransohoff, J. D., Wei, Y. & Khavari, P. A. Nat. Rev. Mol. Cell Biol. 19, 143–157 (2018).

    CAS  Article  Google Scholar 

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Correspondence to Andrej Lupták.

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Chen, C.C., Lupták, A. Hunting for human ribozymes. Nat Chem Biol (2021).

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