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NON-CODING RNA

Hunting for human ribozymes

An approach based on enrichment of 5′ hydroxylated RNAs reveals a new self-cleaving ribozyme that maps to a very long non-protein-coding RNA in simians. The ribozyme is active only among hominin sequences, suggesting a recent acquisition of the activity.

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Fig. 1: Discovery of the hovlinc ribozyme.

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Correspondence to Andrej Lupták.

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Chen, C.C., Lupták, A. Hunting for human ribozymes. Nat Chem Biol (2021). https://doi.org/10.1038/s41589-021-00778-7

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