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Redox-coupled rhythm and brews

A genetically encoded real-time redox reporter reveals that H2O2-signaling peroxiredoxin (PRX) proteins couple yeast metabolic oscillations with the cell division cycle. This new PRX function suggests fresh avenues for exploring circadian regulation of cell division and cancer.

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Fig. 1: Respiratory oscillations impose metabolic checkpoints on cell cycle progression in S. cerevisiae.


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Correspondence to John S. O’Neill.

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O’Neill, J.S. Redox-coupled rhythm and brews. Nat Chem Biol 17, 373–374 (2021).

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