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ANXious for YAP

YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.

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Fig. 1: Small-molecule targeting of the Hippo pathway.


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Correspondence to Toshiro Moroishi.

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Moroishi, T. ANXious for YAP. Nat Chem Biol 17, 750–751 (2021).

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