YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.
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Moroishi, T. ANXious for YAP. Nat Chem Biol 17, 750–751 (2021). https://doi.org/10.1038/s41589-021-00766-x