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POST-TRANSLATIONAL MODIFICATIONS

Deform the membrane, cAPTure the lipid

Acyl protein thioesterases are critical regulators of S-acylation, removing acyl chains from dynamically S-acylated proteins. A cytosolic deacylase, APT2, is S-acylated by zDHHC3 and zDHHC7 and is predicted to deform the lipid bilayer to extract acyl chains, capturing them within a hydrophobic pocket.

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Fig. 1: Kinetic membrane trapping and release of peripheral membrane proteins by dynamic S-acylation.

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Correspondence to Jennifer Greaves.

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Greaves, J. Deform the membrane, cAPTure the lipid. Nat Chem Biol 17, 371–372 (2021). https://doi.org/10.1038/s41589-021-00754-1

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