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Orphan receptor GPR37L1 remains unliganded

The Original Article was published on 19 December 2016

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Fig. 1: The corrected GPR37L1 construct does not have the apparent Gαs constitutive activity seen with p426-r37L1.
Fig. 2: The corrected GPR37L1 construct does not display constitutive or ligand-induced activity in any assays examined.

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We would like to thank R.M. Graham from the Victor Chang Cardiac Research Institute, Australia, for helpful discussions, T. Nettleton from UNSW Sydney for assistance with identifying the cloning error and A. Inoue from Tohoku University for providing the AP–TGF-α constructs and helpful advice. Funding was provided by an NHMRC CJ Martin Early Career Fellowship (1145746 to T.N.), the NIH (R01 AI118985 and R01 GM117424 to I.K.) and a National Heart Foundation Future Leader Fellowship (101153 to N.J.S.).

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Authors and Affiliations



N.J.S., J.L.J.C., S.S.S. and B.P.W. discovered the cloning error. N.J.S., I.K., T.N., B.P.W., S.S.S. and J.L.J.C. devised the experimental plan for correcting the scientific record. T.N., B.P.W., S.S.S., P.K. and K.K.C. performed experiments. A.M.F. assisted with experimental design. N.J.S., I.K. and T.N. wrote the manuscript with input from all of the authors.

Corresponding authors

Correspondence to Irina Kufareva or Nicola J. Smith.

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The authors declare no competing interests.

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Source data

Source Data Fig. 1

Statistical source data.

Source Data Fig. 1

Uncropped western blot.

Source Data Fig. 2

Statistical source data.

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Ngo, T., Wilkins, B.P., So, S.S. et al. Orphan receptor GPR37L1 remains unliganded. Nat Chem Biol 17, 383–386 (2021).

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