Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell death

STACKing the odds for discoveries

Characterization of cell death kinetics identifies new on- and off-target small-molecule modulators of ferroptosis and reveals a role of amino acid metabolism in regulating ferroptosis sensitivity.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: STACK reveals on- and off-target modulators of ferroptosis.


  1. Galluzzi, L. et al. Cell Death Differ. 25, 486–541 (2018).

    Article  Google Scholar 

  2. Conlon, M. et al. Nat. Chem. Biol. (2021).

  3. Dixon, S. J. et al. Cell 149, 1060–1072 (2012).

    Article  CAS  Google Scholar 

  4. Soula, M. et al. Nat. Chem. Biol. 16, 1351–1360 (2020).

    Article  CAS  Google Scholar 

  5. Zhang, Y. et al. Cell Chem. Biol. 26, 623–633.e9 (2019).

    Article  CAS  Google Scholar 

  6. Ubellacker, J. M. et al. Nature 585, 113–118 (2020).

    Article  CAS  Google Scholar 

  7. Viswanathan, V. S. et al. Nature 547, 453–457 (2017).

    Article  CAS  Google Scholar 

  8. Fallahi-Sichani, M., Honarnejad, S., Heiser, L. M., Gray, J. W. & Sorger, P. K. Nat. Chem. Biol. 9, 708–714 (2013).

    Article  CAS  Google Scholar 

  9. Forcina, G. C., Conlon, M., Wells, A., Cao, J. Y. & Dixon, S. J. Cell Syst. 4, 600–610.e6 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kıvanç Birsoy.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Soula, M., Birsoy, K. STACKing the odds for discoveries. Nat Chem Biol 17, 627–628 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing