Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state

An Addendum to this paper has been published: https://doi.org/10.1038/s41589-021-00741-6

Addendum to: Nature Chemical Biology https://doi.org/10.1038/s41589-019-0278-6, published online 13 May 2019

In the version of this Brief Communication originally published, the compound used in Fig. 2a and Supplementary Fig. 4 was misrepresented as MCC950, while it was in fact a closely related derivative. The presented data were updated from those newly collected using the intended MCC950 compound. Furthermore, the sentence “After 100 ns of MD simulations, cluster 2 residues within Walker B presented a more favorable binding energy to MCC950 (Supplementary Fig. 4d), with F304 establishing stacking interactions with F257 and the aromatic ring of MCC950 (Supplementary Fig. 4b,e)” in the main text would have read “After 100 ns of MD simulations, cluster 2 residues within Walker B presented a more favorable binding energy to MCC950 (Supplementary Fig. 4d), with F257 establishing stacking and hydrophobic interactions with the aromatic ring of MCC950 (Supplementary Fig. 4b,e),” given the data on the proper MCC950 compound. A revised Fig. 2a and Supplementary Information PDF are included in the Addendum.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pablo Pelegrin.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tapia-Abellán, A., Angosto-Bazarra, D., Martínez-Banaclocha, H. et al. Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state. Nat Chem Biol 17, 361 (2021). https://doi.org/10.1038/s41589-021-00741-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-021-00741-6

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing