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Overcoming epigenetic roadblocks

Reprogramming requires resetting the epigenome toward a pluripotent chromatin state. A new chemical screen identifies epigenetic and signaling roadblocks for reprogramming of human somatic cells, with the inhibition of these roadblocks resulting in a more permissive epigenome for reprogramming.

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Fig. 1: Targeted chemical inhibition alters the epigenome of somatic cells toward a more permissive state for reprogramming.


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Correspondence to Hendrik Marks.

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Raas, M.W.D., Zijlmans, D.W. & Marks, H. Overcoming epigenetic roadblocks. Nat Chem Biol 17, 6–7 (2021).

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