Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.
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den Besten, W., Lipford, J.R. Prospecting for molecular glues. Nat Chem Biol 16, 1157–1158 (2020). https://doi.org/10.1038/s41589-020-0620-z
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DOI: https://doi.org/10.1038/s41589-020-0620-z
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