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PROTEOSTASIS/DRUG DISCOVERY

A stress-free stress response

A new molecule that specifically activates a key protein homeostasis pathway has been identified. The ability to initiate the IRE1–XBP1s branch of the unfolded protein response opens up new avenues for basic research and treatment of disease.

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Fig. 1: Screening pipeline for specific activators of the IRE1–XBP1s pathway.

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Correspondence to Rebecca C. Taylor.

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Cummins, N., Taylor, R.C. A stress-free stress response. Nat Chem Biol 16, 1038–1039 (2020). https://doi.org/10.1038/s41589-020-0616-8

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