Chemically induced protein–protein interaction

Discovering Nature’s super glue

Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Manumycin polyketides function as covalent molecular glues between UBR7 and TP53.


  1. 1.

    Stanton, B. Z. et al. Science 359, eaao5902 (2018).

    Article  Google Scholar 

  2. 2.

    Isobe, Y. et al. Nat. Chem. Biol. (2020).

    Article  Google Scholar 

  3. 3.

    Crews, C. M. Chem. Biol. 17, 551–555 (2010).

    CAS  Article  Google Scholar 

  4. 4.

    Ito, T. et al. Science 327, 1345–1350 (2010).

    CAS  Article  Google Scholar 

  5. 5.

    Lu, G. et al. Science 343, 305–309 (2014).

    CAS  Article  Google Scholar 

  6. 6.

    Krönke, J. et al. Science 343, 301–305 (2014).

    Article  Google Scholar 

  7. 7.

    Han, T. et al. Science 356, eaal3755 (2017).

    Article  Google Scholar 

  8. 8.

    Uehara, T. et al. Nat. Chem. Biol. 13, 675–680 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Ting, T. C. et al. Cell Rep. 29, 1499–1510.e1496 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Ho, T. T., Tran, Q. T. & Chai, C. L. Future Med. Chem. 10, 1361–1368 (2018).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Ting Han.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zeng, Z., Han, T. Discovering Nature’s super glue. Nat Chem Biol (2020).

Download citation