Chemically induced protein–protein interaction

Discovering Nature’s super glue

Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.

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Fig. 1: Manumycin polyketides function as covalent molecular glues between UBR7 and TP53.

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Correspondence to Ting Han.

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Zeng, Z., Han, T. Discovering Nature’s super glue. Nat Chem Biol (2020). https://doi.org/10.1038/s41589-020-0586-x

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