SIGNAL TRANSDUCTION

Decoding GEFs of animated cells

Rho family GTPases regulate cell behaviors through complex signaling networks that act on rapid timescales in subcellular spatial domains. New live-cell biosensors and analytical methods now provide critical tools to dissect Rho GTPase regulation and to better understand cellular information processing.

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Fig. 1: FRET-based biosensors to reveal complex Rho GEF activities.

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Correspondence to Sean R. Collins.

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Natwick, D.E., Collins, S.R. Decoding GEFs of animated cells. Nat Chem Biol 16, 812–813 (2020). https://doi.org/10.1038/s41589-020-0570-5

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