Extended Data Fig. 2: µOR compartmentalization and diffusion classes. | Nature Chemical Biology

Extended Data Fig. 2: µOR compartmentalization and diffusion classes.

From: Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors

Extended Data Fig. 2

a, Diffraction limited image of representative live-cell with dual-color acquisition of µORs (magenta) and actin (green)-(See also Supplementary Video 1). Note that the receptor spots in the bottom right corner belong to another cell that does not express LifeAct. b, Super-resolved image of the cell in (a) showing that the µOR is compartmentalized by actin fibers. The track-color corresponds with the type of diffusion (magenta = directed diffusion, blue= confined diffusion, cyan= Brownian motion and brown= immobile) (See also Supplementary Video 2) [Shown images are representative of five independent experiments].

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